#330--There's a large number of negative health effects possible when taking oral contraceptives--from depression to weight gain to blood clots. And that should really come as no surprise. Any time you do something which impacts one hormone, you impact all of the others in the body. It's like playing pool except you have more than 15 hormones involved in this game. So unless you're the Minnesota Fats of Endocrinology, you might want to think twice about taking the pill.